Latest Research
-
10 Apr
Xuerui Yang's Research Team Introduces…
Cell heterogeneity is essential for the physiological functions of complex tissues under normal and disease conditions. Systematic interpretation of heterogeneous cell populations and precise identification of key cell subtypes hold substantial importance in gaining critical insights into tissue development, physiological functions, cellular interactions, and the dynamic progression of diseases...
-
10 Apr
A gut-derived hormone, Cholesin, regul…
On March 18th, a research paper titled "A gut-derived hormone regulates cholesterol metabolism" was published in the journal Cell by a team led by Drs. Yiguo Wang from the School of Life Sciences at Tsinghua University and Huijie Zhang from the affiliated Nanfang Hospital of Southern Medical University. This research unveiled a novel intestinal hormone named Cholesin and elucidated its role and...
-
01 Apr
Qiaoran Xi’s group and Liwei Zhang’s…
Diffuse intrinsic pontine glioma (DIPG) is the most aggressive pediatric brainstem tumor with a median survival of less than 12 months; seeking effective therapy is still the focus of the field. Nearly 80% DIPG cells harbor H3K27M mutations, which caused global reduction in H3K27me3 levels, and H3K27M are considered as driver mutations for DIPG. This understanding has recently inspired substant...
-
22 Jan
Wei Xie’s group published research on…
During early mammalian development, the totipotent zygote undergoes the first cell fate decision to form a blastocyst that includes inner cell mass (ICM) and trophectoderm (TE). ICM will give rise to epiblast, which generates all future embryonic lineages, and primitive endoderm (PrE), which forms future yolk sac. By contrast, trophectoderm primarily differentiates to the placenta that supports...
-
01 Sep
Guangshuo Ou’s group published resear…
Guangshou Ou’s group at School of Life Sciences at Tsinghua University published an article entitled "Modulation of inner junction proteins contributes to axoneme differentiation" in the journal Proceedings of the National Academy of Sciences of the United States of America (PNAS) on July 18, 2023, reporting on the mechanism and function of axoneme differentiation.Cilia are organelles widely d...
-
18 Dec
Qiaoran Xi's group and Yi Lin's group …
The transforming growth factor β (TGF-β) signaling pathway plays important roles in the regulation of tissue homeostasis, immune response, tumorigenesis and early mammalian mesodermal differentiation. It has been reported that TRIM33, as a member of TRIM family, plays a key role in the Nodal signaling pathway and regulates mesendoderm differentiation. The protein levels of TRIM33 had no obvio...
-
06 Oct
Zhucheng Chen’s group and collaborato…
DNA in eukaryotes wraps around the histone octamer by ~1.7 turns to form nucleosomes, the fundamental unit of chromatin. The N-termini of histone H4 interact with nearby nucleosomes, and play an important role in the formation of high order chromatin structure and heterochromatin silencing. The formation of nucleosome and heterochromatin hinders genomic DNA functions, such as replication, trans...
-
24 Sep
Qiaoran Xi’s group published research…
Transforming growth factor β (TGF-β) superfamily proteins are potent regulators of cellular development and differentiation. Nodal/Activin/TGF-β and BMP ligands are both present in the intra- and extracellular milieu during early development, and cross-talk between these two branches of developmental signaling is currently the subject of intense research focus.The heart is one of the earlies...
-
22 Sep
Jijie Chai and collaborators publish a…
During the long-term fighting against pathogens, plants have evolved a sophisticated innate immune system to defend against infection. Plants pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns (PAMPs) or host-derived danger-associated molecular patterns (DAMPs) to activate an immune response termed pattern-triggered immunity (PTI). PRRs are mainly composed of rece...
-
09 Sep
Wei Xie’s group, Zi-Jiang Chen’s gro…
A joint team led by Prof. Wei Xie at Tsinghua University, Prof. Zi-Jiang Chen and Prof. Han Zhao from Shandong University, has charted the translational landscapes during the human oocyte-to-embryo transition (OET). This dataset further identified a group of homeobox TFs, including TPRXL, TPRX1, and TPRX2, which are highly translated around ZGA, and are required for proper ZGA and preimplantati...