Latest Research
-
03 Aug
Qiaoran Xi’s group and Liwei Zhang’s…
Diffuse intrinsic pontine glioma (DIPG) is a rare and incurable pediatric brain cancer with survival of less than one year. Understanding the tumorigenesis mechanisms of DIPG and identifying potential new therapeutic strategy are major research foci in the DIPG field.On August 01, 2022, Qiaoran Xi’s research group from Tsinghua University and Liwei Zhang’s research group from Beijing Tiantan ...
-
13 Jul
The transcriptional regulatory functio…
Despite the fundamental roles of TGF-β family signaling in cell fate determination in all metazoans, the mechanism by which these signals are spatially and temporally interpreted remains elusive. The cell context-dependent function of TGF-β signaling largely relies on transcriptional regulation by SMAD proteins.On July 12, 2022, Qiaoran Xi’s research group from Tsinghua University published ...
-
13 Jul
A Nodal enhanced micropeptide NEMEP re…
TGF-β family proteins including Nodal are known as central regulators of early development in metazoans. For example, Nodal signaling initiates gastrulation in vivo and promotes embryonic stem cells (ESCs) to differentiate towards mesendoderm fates in vitro; these regulatory processes are mediated by the transcriptional upregulation of so-called “mesendoderm lineage determining transcription ...
-
12 Jul
Jijie Chai’s research group with coll…
Crop diseases cause about loss of ~ $ 220 billion annually. Controlling of crop diseases without compromising agricultural traits has been a long-sought dream of crop breeders. A key to this end is to identify conserved and natural immune signaling molecules with a broad spectrum of pathogen resistance activity. Pathogens exude pathogenic factors known as pathogen effectors into plant cells dur...
-
17 Jun
Wei Xie’s group and Lei Li’s group p…
Translation plays a key role in gene expression regulation and development. During mammalian oocyte maturation and early embryonic development, transcription is largely silenced from the full-grown oocyte until zygotic genome activation (ZGA). Therefore, during the oocyte-to-embryo transition (OET), translational regulation plays important roles in meiotic resumption, fertilization, and ZGA. Ho...
-
02 Apr
Liang Ge's group discovered a novel ag…
On April 1, 2022, Liang Ge's research group at the School of Life Sciences, Tsinghua University published a research article online in the journal "Cell" titled with “CCT2 is an aggrephagy receptor for clearance of solid protein aggregates”, discovered a novel aggrephagy receptor CCT2 and its important role in the clearance of solid protein aggregates.Aggrephagy is an important way to clear i...
-
23 Jan
Xinquan Wang and collaborators reveal …
SARS-CoV-2 is responsible for the ongoing global COVID-19 pandemic, posing serious threat to public health. The exact origin and zoonotic transmission route of the SARS-CoV-2 are still unknown. The Spike (S) glycoprotein of coronaviruses mediates viral entry by binding host receptor and fusing viral and cellular membranes. And the molecular evolution of sequence and structures of spike affe...
-
27 Dec
Wei Xie’s group published research on…
Prof. Wei Xie’s group at School of Life Science, Tsinghua University published research in Science Advances on December 22, 2021, entitled “Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs”. Their findings not only greatly deepen our fundamental understanding on how DNA methylation regulates early embryonic development in zebrafish, b...
-
11 Jul
Zhucheng Chen’s group at Tsinghua Uni…
Recently, Professor Zhucheng Chen’s group at the School of Life Science reports the crystal structure of human ALC1 (amplification in liver cancer 1，also known as CHD1L：chromodomain helicase/ATPase DNA binding protein 1-like) and the cryo-EM structure bound to the nucleosome. In combination with biochemical analyses, their findings shed light on the regulation mechanisms of the enzyme, pavin...
-
09 Jul
A new study elucidates an important me…
In a paper published online in the PLOS Biology on July 6, 2021, Jun Yao and coauthors of Tsinghua University reported their findings in the mechanism involving the deficits of Synaptotagmin-7-mediated activation of spontaneous NMDAR currents in bipolar disorder (BD), which is a complex neuropsychiatric disorder characterized by intermittent episodes of mania and depression.Neurotransmitter rel...